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KMID : 0978920220230020115
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Korean Journal of Clinical Geriatrics
2022 Volume.23 No. 2 p.115 ~ p.122
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A Study on The Efficacy of Vaccination in Elderly Patients with Breakthrough COVID-19 Infection
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Choi Soo-Bok
Choi Zi-On
Ha Chul-Min
Lee Hyoung-Ju
Kim Chong-Myung
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Abstract
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Background: Old age is one of the risk factors for COVID-19, and previous studies, mainly in the U.S., have shown that the COVID-19 vaccine has obvious efficacy in reducing the morbidity and progression to severe disease. This study focused on whether vaccination affects the disease progression in elderly COVID-19 patients in South Korea.
Methods: We divided COVID-19 patients over 65 years of age hospitalized at a single medical institution into a vaccinated group and an unvaccinated group, a the progression group and the improvement group, and cross-analyzed them with a chi-square test, and then obtained the odds ratio by binary logistic regression analysis.
Results: Of the total patients, 14 (4.3%) in the vaccinated group (n=323) and 29 (23.4%) in the unvaccinated group (n=124) were in the progression group, showing a significant difference (P=0.000). Subsequent binary logistic regression analysis showed that the odds ratio was 0.112 (P=0.000), indicating that vaccination had a significant effect on reducing the progression to severe disease.
Conclusion: The COVID-19 vaccine is effective in reducing progression to severe disease in older patients with breakthrough infection, and vaccination is recommended for elderly patients.
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KEYWORD
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Aged, COVID-19, Disease progression, Vaccination
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